| Title : Tyrosinase inhibition by a rare neolignan: Inhibition kinetics and mechanistic insights through in vitro and in silico studies - Sohretoglu_2018_Comput.Biol.Chem_76_61 |
| Author(s) : Sohretoglu D , Sari S , Barut B , Ozel A |
| Ref : Comput Biol Chem , 76 :61 , 2018 |
|
Abstract :
Neolignans are a large group of polyphenols found in plants and exhibit a wide range of bioactivities including cytotoxicity, apoptosis inducer, antimalarial and antifungal effects, acetylcholinesterase, tyrosinase, and alpha-glucosidase inhibition. In this study we tested acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), tyrosinase, and alpha-glucosidase inhibitory effects of a rare neolignan, (-)-4-O-methyldehydrodiconiferyl alcohol 9'-O-beta-glucopyranoside (1) in search for its new pharmaceutical effects. This compound exhibited good tyrosinase inhibition with an IC50 value of 44.62+/-3.99mug/mL. Enzyme kinetics and molecular modelling studies were performed to provide insights into its tyrosinase inhibition mechanism. |
| PubMedSearch : Sohretoglu_2018_Comput.Biol.Chem_76_61 |
| PubMedID: 29957363 |
Sohretoglu D, Sari S, Barut B, Ozel A (2018)
Tyrosinase inhibition by a rare neolignan: Inhibition kinetics and mechanistic insights through in vitro and in silico studies
Comput Biol Chem
76 :61
Sohretoglu D, Sari S, Barut B, Ozel A (2018)
Comput Biol Chem
76 :61