Sokolove_1986_FEBS.Lett_203_121

Reference

Title : Phenolic antioxidants: potent inhibitors of the (Ca2+ + Mg2+)-ATPase of sarcoplasmic reticulum - Sokolove_1986_FEBS.Lett_203_121
Author(s) : Sokolove PM , Albuquerque EX , Kauffman FC , Spande TF , Daly JW
Ref : FEBS Letters , 203 :121 , 1986
Abstract :

Bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane (bis-phenol) is the most potent inhibitor of the (Ca2+ + Mg2+)-ATPase of skeletal muscle sarcoplasmic reticulum yet identified. The compound behaves as a reversible, tight-binding inhibitor with apparent Ki = 0.3 microM. Butylated hydroxytoluene, butylated hydroxyanisole, and 4-nonylphenol are also effective inhibitors. These observations are of particular interest in light of the widespread use of such phenolic antioxidants and stabilizers in the food industry and in the manufacture of rubbers and plastics and the ease with which the compounds are extracted into organic solvents.

PubMedSearch : Sokolove_1986_FEBS.Lett_203_121
PubMedID: 2942419

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Citations formats

Sokolove PM, Albuquerque EX, Kauffman FC, Spande TF, Daly JW (1986)
Phenolic antioxidants: potent inhibitors of the (Ca2+ + Mg2+)-ATPase of sarcoplasmic reticulum
FEBS Letters 203 :121

Sokolove PM, Albuquerque EX, Kauffman FC, Spande TF, Daly JW (1986)
FEBS Letters 203 :121