| Title : Interaction of acetylcholinesterase inhibitor donepezil with ionic channels of the neuronal membrane - Solntseva_2006_Bull.Exp.Biol.Med_142_387 |
| Author(s) : Solntseva EI , Bukanova YV , Skrebitskii VG |
| Ref : Bulletin of Experimental Biology & Medicine , 142 :387 , 2006 |
|
Abstract :
The effects of donepezil on voltage-dependent Ca(2+)- and low-threshold K(+)-current were studied on isolated molluscan neurons using two-electrode voltage clamp technique. Donepezil reduced the amplitude of voltage-dependent Ca(2+)-current (IC(50)=7.9 microM) and shifted the current-voltage relationships toward hyperpolarization. Donepezil in low concentration (5 microM) increased, while in higher concentrations (>or=10 microM) decreased the low-threshold K(+)-current. |
| PubMedSearch : Solntseva_2006_Bull.Exp.Biol.Med_142_387 |
| PubMedID: 17415417 |
Solntseva EI, Bukanova YV, Skrebitskii VG (2006)
Interaction of acetylcholinesterase inhibitor donepezil with ionic channels of the neuronal membrane
Bulletin of Experimental Biology & Medicine
142 :387
Solntseva EI, Bukanova YV, Skrebitskii VG (2006)
Bulletin of Experimental Biology & Medicine
142 :387