Solsona_1990_J.Physiol.Paris_84_174

Reference

Title : The action of botulinum toxin on cholinergic nerve terminals isolated from the electric organ of Torpedo marmorata. Detection of a putative toxin receptor - Solsona_1990_J.Physiol.Paris_84_174
Author(s) : Solsona C , Egea G , Blasi J , Casanova C , Marsal J
Ref : Journal de Physiologie (Paris) , 84 :174 , 1990
Abstract :

Botulinum neurotoxin type A (BoNTx) inhibits the release of acetylcholine (ACh) from Torpedo electric organ synaptosomes. We have studied several biochemical and morphological aspects in order to characterize the molecular interactions of BoNTx intoxication in our preparation. 1. We are describing for the first time an electrophoretic band from cholinergic presynaptic plasma membrane (PSPM) that is recognized by 125I-BoNTx as a putative BoNTx receptor. 2. Furthermore we describe direct interaction of botulinum toxin-gold complexes with synaptic vesicles through the three-step model of the BoNTx intoxication.

PubMedSearch : Solsona_1990_J.Physiol.Paris_84_174
PubMedID: 1963197

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Citations formats

Solsona C, Egea G, Blasi J, Casanova C, Marsal J (1990)
The action of botulinum toxin on cholinergic nerve terminals isolated from the electric organ of Torpedo marmorata. Detection of a putative toxin receptor
Journal de Physiologie (Paris) 84 :174

Solsona C, Egea G, Blasi J, Casanova C, Marsal J (1990)
Journal de Physiologie (Paris) 84 :174