Song_2010_Ageing.Res.Rev_9 Suppl 1_S6

Studies of senile dementia (SD) on the Chinese mainland, done over the decades, have furthered the understanding of its epidemiology, basic and clinical medical aspects, and effects on health economics, to name a few areas. There are 6-7 million Chinese people with SD, with an incidence of 5-7% of people over 65 years of age. In this group, Alzheimer's accounts for 50-60% of SD. The pathogenesis of Alzheimer's disease has been investigated, and known risk factors include beta-amyloid, formaldehyde, acetyl cholinesterase, inflammation, neuronal dysfunction and death. Mild cognitive impairment (MCI) is an independent risk factor of SD. Comprehensive treatment can improve clinical efficacy, and quality of life can be improved by appropriate and reasonable care and rehabilitation therapy. However, swallowing disorders, infection and systemic failure remain the main causes of death among SD patients. In the Chinese mainland, SD extracts a total annual economic loss of 83.5-97.4 billion yuan and is responsible for 51.3-59.8 billion yuan in annual healthcare costs. Despite the progress to date, basic research and drug development for SD are needed. Also, a more evidence-based approach to Chinese medicine research would be prudent. Such research results can hopefully provide valuable cues for governmental decision-making and assist in addressing and halting the incidence of SD in China.