Song_2022_Phytochemistry__113506

Reference

Title : Steroid glycosides from the roots of Marsdenia tenacissima - Song_2022_Phytochemistry__113506
Author(s) : Song XQ , Tian LL , Ye T , Liu H , Zhang H
Ref : Phytochemistry , :113506 , 2022
Abstract :

Eleven undescribed glycosylated C(21) steroids and nine known homologous glycosides with diverse acyl substituents, as well as their common steroid aglycone, have been obtained from the roots of Marsdenia tenacissima. Their structures were elucidated mainly by comprehensive spectroscopic analyses and comparison with previously reported analogues, with the absolute configuration assignment being supported by chemical degradation, X-ray crystallography and ECD exciton chirality method. Among them, two pairs of regioisomers were found to exist as inseparable equilibrium mixtures due to an interesting intramolecular transesterification, and nicotinoyl substitution was first reported for metabolites from the title plant. Screening of these compounds in a panel of bioassays revealed that two glycosides displayed mild inhibition against butyrylcholinesterase.

PubMedSearch : Song_2022_Phytochemistry__113506
PubMedID: 36347308

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Citations formats

Song XQ, Tian LL, Ye T, Liu H, Zhang H (2022)
Steroid glycosides from the roots of Marsdenia tenacissima
Phytochemistry :113506

Song XQ, Tian LL, Ye T, Liu H, Zhang H (2022)
Phytochemistry :113506