Title : Effect of oxiracetam and piracetam on central cholinergic mechanisms and active-avoidance acquisition - Spignoli_1986_Clin.Neuropharmacol_9 Suppl 3_S39 |
Author(s) : Spignoli G , Pedata F , Giovannelli L , Banfi S , Moroni F , Pepeu G |
Ref : Clinical Neuropharmacology , 9 Suppl 3 :S39 , 1986 |
Abstract :
Oxiracetam at 100 and 300 mg/kg i.p. dose levels increased acetylcholine (ACh) utilization in the rat cerebral cortex and hippocampus. ACh utilization was assessed by measuring, with a gas chromatographic method, the decrease in ACh level after inhibiting its synthesis by 15 micrograms intracerebroventricularly (i.c.v.) injection of hemicholinium (HC-3). ACh steady state levels were not affected. Piracetam (300 mg/kg i.p.) also increased ACh utilization in the hippocampus. Repeated daily administration of oxiracetam 100 mg/kg i.p. caused a 31% increase in high-affinity choline uptake (HACU) in the hippocampus. A single administration of 300 mg/kg i.p. of oxiracetam and piracetam also increased HACU rate in the hippocampus. However, the effect of piracetam was over within 3 h, while 3 h after its administration oxiracetam still caused a 40% increase in HACU rate. Oxiracetam (100 mg/kg i.p.) significantly antagonized the impairment in the acquisition of an active-avoidance conditioned response (pole climbing) associated with the inhibition of ACh synthesis by HC-3. These results indicate that oxiracetam enhances the activity of the septohippocampal cholinergic pathways, and to a lesser extent, of the cortical cholinergic network. |
PubMedSearch : Spignoli_1986_Clin.Neuropharmacol_9 Suppl 3_S39 |
PubMedID: 3594455 |
Spignoli G, Pedata F, Giovannelli L, Banfi S, Moroni F, Pepeu G (1986)
Effect of oxiracetam and piracetam on central cholinergic mechanisms and active-avoidance acquisition
Clinical Neuropharmacology
9 Suppl 3 :S39
Spignoli G, Pedata F, Giovannelli L, Banfi S, Moroni F, Pepeu G (1986)
Clinical Neuropharmacology
9 Suppl 3 :S39