Spirin_2007_Am.J.Hum.Genet_81_1298

Reference

Title : Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol - Spirin_2007_Am.J.Hum.Genet_81_1298
Author(s) : Spirin V , Schmidt S , Pertsemlidis A , Cooper RS , Cohen JC , Sunyaev SR
Ref : American Journal of Human Genetics , 81 :1298 , 2007
Abstract :

The identification of DNA sequence variants underlying human complex phenotypes remains a significant challenge for several reasons: individual variants can have small phenotypic effects or low population frequencies, and multiple allelic variants may act in concert to affect a trait. We evaluated the combined effect of allelic variants in seven genes involved in high-density lipoprotein (HDL) metabolism, using forward stepwise regression. Analysis of all known common single-nucleotide polymorphisms (SNPs) in the seven candidate genes revealed four variants that were associated with incremental changes in HDL cholesterol levels in three independent samples. Conversely, analysis of 660 polymorphisms in eight genes that do not appear to be involved in HDL metabolism did not identify any associations with plasma HDL-cholesterol levels. These data indicate that several common SNPs act in concert to influence plasma levels of HDL cholesterol.

PubMedSearch : Spirin_2007_Am.J.Hum.Genet_81_1298
PubMedID: 17952847

Related information

Citations formats

Spirin V, Schmidt S, Pertsemlidis A, Cooper RS, Cohen JC, Sunyaev SR (2007)
Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol
American Journal of Human Genetics 81 :1298

Spirin V, Schmidt S, Pertsemlidis A, Cooper RS, Cohen JC, Sunyaev SR (2007)
American Journal of Human Genetics 81 :1298