Srivastava_2000_Vet.Hum.Toxicol_42_212

The effect of iv diacetylmonoxime (DAM) alone or in combination with atropine was determined on blood enzymatic activities in fenitrothion-exposed buffalo calves. Fenitrothion given po at 435 mg/kg bw produced pronounced inhibition of blood acetylcholinesterase (AChE) and elevation in serum aspartate and alanine aminotransferases, acid and alkaline phosphatases, and lactate dehydrogenase within 30 min. The administration of DAM alone or in combination with atropine significantly reactivated AChE activity. The administration of DAM + atropine decreased serum aspartate and alanine aminotransferase enzymes within 1-3 d. The reversal effect of DAM + atropine on serum phosphatases and lactate dehydrogenase was greater than that of DAM or atropine alone.