Stevens_1987_Neurosci.Lett_79_301

Reference

Title : Excitatory actions of tetrahydro-9-aminoacridine (THA) on hippocampal pyramidal neurons - Stevens_1987_Neurosci.Lett_79_301
Author(s) : Stevens DR , Cotman CW
Ref : Neuroscience Letters , 79 :301 , 1987
Abstract :

The action of tetrahydro-9-aminoacridine (THA) on guinea pig pyramidal neurons was examined using intracellular recording in an in vitro hippocampal slice preparation. THA had a powerful excitatory action on pyramidal neurons, causing depolarization, increased firing, and an increase in input resistance. This excitatory action of THA persisted in atropine and in tetrodotoxin. The estimated reversal potential of this THA effect was near -90 mV. These results indicate that THA has a direct excitatory action on pyramidal neurons independent of its anticholinesterase activity, resulting from blockade of a conductance carried predominantly by potassium ions.

PubMedSearch : Stevens_1987_Neurosci.Lett_79_301
PubMedID: 3658222

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Citations formats

Stevens DR, Cotman CW (1987)
Excitatory actions of tetrahydro-9-aminoacridine (THA) on hippocampal pyramidal neurons
Neuroscience Letters 79 :301

Stevens DR, Cotman CW (1987)
Neuroscience Letters 79 :301