| Title : Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors - Storz_2012_J.Am.Chem.Soc_134_16143 |
| Author(s) : Storz MP , Maurer CK , Zimmer C , Wagner N , Brengel C , de Jong JC , Lucas S , Musken M , Haussler S , Steinbach A , Hartmann RW |
| Ref : Journal of the American Chemical Society , 134 :16143 , 2012 |
| Abstract : 2-Heptyl-4-hydroxyquinoline (HHQ) and Pseudomonas quinolone signal (PQS) are involved in the regulation of virulence factor production and biofilm formation in Pseudomonas aeruginosa. PqsD is a key enzyme in the biosynthesis of these signal molecules. Using a ligand-based approach, we have identified the first class of PqsD inhibitors. Simplification and rigidization led to fragments with high ligand efficiencies. These small molecules repress HHQ and PQS production and biofilm formation in P. aeruginosa. This validates PqsD as a target for the development of anti-infectives. |
| ESTHER : Storz_2012_J.Am.Chem.Soc_134_16143 |
| PubMedSearch : Storz_2012_J.Am.Chem.Soc_134_16143 |
| PubMedID: 22992202 |
Storz MP, Maurer CK, Zimmer C, Wagner N, Brengel C, de Jong JC, Lucas S, Musken M, Haussler S, Steinbach A, Hartmann RW (2012)
Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors
Journal of the American Chemical Society
134 :16143
Storz MP, Maurer CK, Zimmer C, Wagner N, Brengel C, de Jong JC, Lucas S, Musken M, Haussler S, Steinbach A, Hartmann RW (2012)
Journal of the American Chemical Society
134 :16143