Struble_2010_J.Alzheimers.Dis_22_393

Reference

Title : Is brain amyloid production a cause or a result of dementia of the Alzheimer's type? - Struble_2010_J.Alzheimers.Dis_22_393
Author(s) : Struble RG , Ala T , Patrylo PR , Brewer GJ , Yan XX
Ref : J Alzheimers Dis , 22 :393 , 2010
Abstract :

The amyloid cascade hypothesis has guided much of the research into Alzheimer's disease (AD) over the last 25 years. We argue that the hypothesis of amyloid-beta (Abeta) as the primary cause of dementia may not be fully correct. Rather, we propose that decline in brain metabolic activity, which is tightly linked to synaptic activity, actually underlies both the cognitive decline in AD and the deposition of Abeta. Abeta may further exacerbate metabolic decline and result in a downward spiral of cognitive function, leading to dementia. This novel interpretation can tie the disparate risk factors for dementia to a unifying hypothesis and present a roadmap for interventions to decrease the prevalence of dementia in the elderly population.

PubMedSearch : Struble_2010_J.Alzheimers.Dis_22_393
PubMedID: 20847431

Related information

Citations formats

Struble RG, Ala T, Patrylo PR, Brewer GJ, Yan XX (2010)
Is brain amyloid production a cause or a result of dementia of the Alzheimer's type?
J Alzheimers Dis 22 :393

Struble RG, Ala T, Patrylo PR, Brewer GJ, Yan XX (2010)
J Alzheimers Dis 22 :393