| Title : Quantitative structure-activity relationships and possible mechanisms of action of bispyridinium oximes as antidotes against pinacolyl methylphosphonofluoridate - Su_1983_Fundam.Appl.Toxicol_3_271 |
| Author(s) : Su CT , Tang CP , Ma C , Shih YS , Liu CY , Wu MT |
| Ref : Fundamental & Applied Toxicology , 3 :271 , 1983 |
|
Abstract :
The antidotal efficacy of bispyridinium oximes against the poisoning by pinacolyl methylphosphonofluoridate can be correlated well with their physicochemical parameters. Good correlation was observed between the efficacy of antagonism against pinacolyl methylphosphonofluoridate and antinicotinic action of these oximes. X-ray structural analysis showed that these oximes possessed structural similarity to nicotine and acetylcholine of nicotinic conformation. A new model of antidotal action, other than reactivation, against the poisoning by pinacolyl methylphosphonofluoridate was proposed for these bispyridinium oximes through nicotinic receptor binding. The antagonistic efficacy of these antidotes against pinacolyl methylphosphonofluoridate may be attributed to their direct antagonism at nicotinic receptor as well as reactivation of inhibited acetylcholinesterase. |
| PubMedSearch : Su_1983_Fundam.Appl.Toxicol_3_271 |
| PubMedID: 6628889 |
Su CT, Tang CP, Ma C, Shih YS, Liu CY, Wu MT (1983)
Quantitative structure-activity relationships and possible mechanisms of action of bispyridinium oximes as antidotes against pinacolyl methylphosphonofluoridate
Fundamental & Applied Toxicology
3 :271
Su CT, Tang CP, Ma C, Shih YS, Liu CY, Wu MT (1983)
Fundamental & Applied Toxicology
3 :271