| Title : The first total synthesis of (+\/-)-arisugacin A, a potent, orally bioavailable inhibitor of acetylcholinesterase - Sunazuka_2002_Org.Lett_4_367 |
| Author(s) : Sunazuka T , Handa M , Nagai K , Shirahata T , Harigaya Y , Otoguro K , Kuwajima I , Omura S |
| Ref : Org Lett , 4 :367 , 2002 |
|
Abstract :
The first convergent total synthesis of (+/-)-arisugacin A was accomplished by stereoselective construction of the arisugacin skeleton via a Knoevenagel-type reaction of an alpha,beta-unsaturated aldehyde with a 4-hydroxy 2-pyrone and stereoselective dihydroxylation followed by deoxygenation. |
| PubMedSearch : Sunazuka_2002_Org.Lett_4_367 |
| PubMedID: 11820881 |
Sunazuka T, Handa M, Nagai K, Shirahata T, Harigaya Y, Otoguro K, Kuwajima I, Omura S (2002)
The first total synthesis of (+\/-)-arisugacin A, a potent, orally bioavailable inhibitor of acetylcholinesterase
Org Lett
4 :367
Sunazuka T, Handa M, Nagai K, Shirahata T, Harigaya Y, Otoguro K, Kuwajima I, Omura S (2002)
Org Lett
4 :367