Title : (+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase - Sung_2002_Biol.Pharm.Bull_25_125 |
Author(s) : Sung SH , Kang SY , Lee KY , Park MJ , Kim JH , Park JH , Kim YC , Kim J |
Ref : Biol Pharm Bull , 25 :125 , 2002 |
Abstract :
In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of 1 and 2 were 2.0 and 115.8 microM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive. |
PubMedSearch : Sung_2002_Biol.Pharm.Bull_25_125 |
PubMedID: 11824541 |
Sung SH, Kang SY, Lee KY, Park MJ, Kim JH, Park JH, Kim YC, Kim J (2002)
(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase
Biol Pharm Bull
25 :125
Sung SH, Kang SY, Lee KY, Park MJ, Kim JH, Park JH, Kim YC, Kim J (2002)
Biol Pharm Bull
25 :125