| Title : Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase - Suresh_2011_Bioorg.Med.Chem.Lett_21_3997 |
| Author(s) : Suresh Kumar R , Ashraf Ali M , Osman H , Ismail R , Choon TS , Yoon YK , Wei AC , Pandian S , Manogaran E |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :3997 , 2011 |
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Abstract :
Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer's disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.72 mumol/L. |
| PubMedSearch : Suresh_2011_Bioorg.Med.Chem.Lett_21_3997 |
| PubMedID: 21621414 |
Suresh Kumar R, Ashraf Ali M, Osman H, Ismail R, Choon TS, Yoon YK, Wei AC, Pandian S, Manogaran E (2011)
Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett
21 :3997
Suresh Kumar R, Ashraf Ali M, Osman H, Ismail R, Choon TS, Yoon YK, Wei AC, Pandian S, Manogaran E (2011)
Bioorganic & Medicinal Chemistry Lett
21 :3997