| Title : Phenyl-n-butylborinic acid is a potent transition state analog inhibitor of lipolytic enzymes - Sutton_1986_Biochem.Biophys.Res.Commun_134_386 |
| Author(s) : Sutton LD , Stout JS , Hosie L , Spencer PS , Quinn DM |
| Ref : Biochemical & Biophysical Research Communications , 134 :386 , 1986 |
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Abstract :
The cholesterol esterase and lipoprotein lipase catalyzed hydrolyses of the water-soluble substrate p-nitrophenyl butyrate are competitively inhibited by butaneboronic acid and phenylboronic acid. Phenyl-n-butylborinic acid has been synthesized and characterized as an ultrapotent transition state analog inhibitor: Ki = 2.9 +/- 0.6 nM and 1.7 +/- 0.3 microM for the cholesterol esterase and lipoprotein lipase reactions, respectively. These results are interpreted in terms of transition state structure and stabilization. |
| PubMedSearch : Sutton_1986_Biochem.Biophys.Res.Commun_134_386 |
| PubMedID: 3947331 |
Sutton LD, Stout JS, Hosie L, Spencer PS, Quinn DM (1986)
Phenyl-n-butylborinic acid is a potent transition state analog inhibitor of lipolytic enzymes
Biochemical & Biophysical Research Communications
134 :386
Sutton LD, Stout JS, Hosie L, Spencer PS, Quinn DM (1986)
Biochemical & Biophysical Research Communications
134 :386