Syad_2012_Evid.Based.Complement.Alternat.Med_2012_497242

The effect of various solvent extracts of Gelidiella acerosa on acetylcholinesterase (AChE) and butyrylcholinesterase (BCHE) activities was investigated. AChE and BCHE inhibitory activities were analyzed by spectrophotometric method. Phytochemical screening of the compounds present in the solvent extracts was done qualitatively. Characterization of the compounds present in the benzene extract of G. acerosa was done by GC-MS analysis. The results showed that, at 487.80 mug/mL, benzene extract showed significant (P < 0.05) inhibitory activity against both AChE and BCHE with the percentage of inhibition 54.18 +/- 5.65 % (IC(50) = 434.61 +/- 26.53 mug/mL) and 78.43 +/- 0% (IC(50) = 163.01 +/- 85.35 mug/mL), respectively. The mode of inhibition exhibited by benzene extract against the AChE and BCHE was found to be competitive and uncompetitive type of inhibition, respectively. Preliminary phytochemical analysis coupled with GC-MS illustrates that the benzene extract possesses high amount of terpenoids, which could be the reason for potential cholinesterase inhibitory activity.