Title : Assessment of amino-terminal C-type natriuretic peptide serum level and its correlation with high-density lipoprotein structure and function in patients with end stage renal disease before and after kidney transplantation - Szentimrei_2023_Chem.Biol.Interact_14ChEPon_385_110749 |
Author(s) : Szentimrei R , Lorincz H , Szentpeteri A , Varga VE , Seres I , Varga , Nemes B , Harangi M , Paragh G |
Ref : Chemico-Biological Interactions , 385 :110749 , 2023 |
Abstract :
We aimed to investigate serum amino-terminal C-type natriuretic peptide (NT-proCNP) and its relationship with quantitative and qualitative HDL-parameters in patients with end-stage renal disease (ESRD) before, then 1 and 6 months after kidney transplantation (TX). Seventy patients (47 males, 23 females, mean age 51.7 +/- 12.4 years) were enrolled in a prospective follow-up study. We examined serum creatinine, C-reactive protein, procalcitonin, fasting glucose and lipid parameters before, then 1 and 6 months after TX. High-density lipoprotein- (HDL)-associated paraoxonase-1 (PON1) paraoxonase and arylesterase activities were measured spectrophotometrically. Lipoprotein subfractions were determined by Lipoprint. NT-proCNP and oxidized low-density lipoprotein (oxLDL) levels were measured by ELISA. Mean NT-proCNP was 45.8 +/- 21.9 pmol/L before renal transplantation and decreased markedly 1 month and 6 months after transplantation (5.3 +/- 2.5 and 7.7 +/- 4.9 pmol/L, respectively, P = 1 x 10(-4)). During the 6 months' follow-up, PON1 arylesterase, paraoxonase and salt-stimulated paraoxonase activities improved. NT-proCNP positively correlated with procalcitonin and creatinine and negatively with GFR, LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C). There was a negative correlation between serum NT-proCNP and PON1 arylesterase activity. According to the multiple regression analysis, the best predicting variables of NT-proCNP were serum procalcitonin, creatinine and PON1 arylesterase activity. NT-proCNP might be a novel link between HDL dysfunction and impaired vascular function in ESRD, but not after kidney transplantation. Further studies in larger populations are needed to clarify the exact role of NT-proCNP in the risk prediction for cardiovascular comorbidities and complications in ESRD. |
PubMedSearch : Szentimrei_2023_Chem.Biol.Interact_14ChEPon_385_110749 |
PubMedID: 37802408 |
Szentimrei R, Lorincz H, Szentpeteri A, Varga VE, Seres I, Varga, Nemes B, Harangi M, Paragh G (2023)
Assessment of amino-terminal C-type natriuretic peptide serum level and its correlation with high-density lipoprotein structure and function in patients with end stage renal disease before and after kidney transplantation
Chemico-Biological Interactions
385 :110749
Szentimrei R, Lorincz H, Szentpeteri A, Varga VE, Seres I, Varga, Nemes B, Harangi M, Paragh G (2023)
Chemico-Biological Interactions
385 :110749