| Title : Identification of hydrophobic tags for the degradation of stabilized proteins - Tae_2012_Chembiochem_13_538 |
| Author(s) : Tae HS , Sundberg TB , Neklesa TK , Noblin DJ , Gustafson JL , Roth AG , Raina K , Crews CM |
| Ref : Chembiochem , 13 :538 , 2012 |
|
Abstract :
New HyTs are a knockout: we previously reported that labeling HaloTag proteins with low molecular weight hydrophobic tags (HyTs) leads to targeted degradation of HaloTag fusion proteins. In this report, we employed a chemical approach to extend this hydrophobic tagging methodology to highly stabilized proteins by synthesizing and evaluating a library of HyTs, which led to the identification of HyT36. |
| PubMedSearch : Tae_2012_Chembiochem_13_538 |
| PubMedID: 22271667 |
| Inhibitor | HyT13 |
Tae HS, Sundberg TB, Neklesa TK, Noblin DJ, Gustafson JL, Roth AG, Raina K, Crews CM (2012)
Identification of hydrophobic tags for the degradation of stabilized proteins
Chembiochem
13 :538
Tae HS, Sundberg TB, Neklesa TK, Noblin DJ, Gustafson JL, Roth AG, Raina K, Crews CM (2012)
Chembiochem
13 :538