Takano_2026_Am.Surg__31348261433635

BackgroundsThis study aimed to evaluate the prognostic value of the cholinesterase-prognostic nutritional index (ChE-PNI) score in patients undergoing curative colorectal resection for colorectal cancer.MethodsThis retrospective study included 628 patients who underwent curative colorectal resection for stage II/III CRC. Preoperative serum ChE levels and PNI were used to calculate the ChE-PNI score, and patients were categorized into 3 groups (score 0, 1, or 2). We investigated the association between the ChE-PNI score and survival outcomes.ResultsAmong all patients, 88 (14%) were classified as the ChE-PNI score of 2. Multivariate analysis revealed that American Society of Anesthesiologists physical status <=3 (P = .009), T stage 3-4 (P = .004), N stage 1-3 (P < .001), ChE-PNI = 2 (P = .031), and serum carcinoembryonic antigen <=5.0 ng/ml (P = .002) were independent predictors of disease-free survival. While, age <=65 (P = .027), Anesthesiologists physical status <=3 (P < .001), N stage 1-3 (P = .013), and ChE-PNI = 2 (P = .005) were independent predictors of overall survival.ConclusionThe ChE-PNI score is a novel, simple, and effective marker that independently predicts postoperative prognosis in patients with colorectal cancer.