| Title : Rational redesign of Candida antarctica lipase B for the ring opening polymerization of D,D-lactide - Takwa_2011_Chem.Commun.(Camb)_47_7392 |
| Author(s) : Takwa M , Larsen MW , Hult K , Martinelle M |
| Ref : Chem Commun (Camb) , 47 :7392 , 2011 |
|
Abstract :
Based on molecular modelling, the enzyme Candida antarctica lipase B was redesigned as a catalyst for the ring opening polymerization of D,D-lactide. Two mutants with 90-fold increased activity as compared to the wild-type enzyme were created. In a preparative synthesis of poly(D,D-lactide) the mutants greatly improved the rate and the degree of polymerization. |
| PubMedSearch : Takwa_2011_Chem.Commun.(Camb)_47_7392 |
| PubMedID: 21607247 |
| Substrate | D-D-lactone |
Takwa M, Larsen MW, Hult K, Martinelle M (2011)
Rational redesign of Candida antarctica lipase B for the ring opening polymerization of D,D-lactide
Chem Commun (Camb)
47 :7392
Takwa M, Larsen MW, Hult K, Martinelle M (2011)
Chem Commun (Camb)
47 :7392