Tanaka_1995_Neurochem.Res_20_663

Reference

Title : Post-ischemic administration of the acetylcholinesterase inhibitor ENA-713 prevents delayed neuronal death in the gerbil hippocampus - Tanaka_1995_Neurochem.Res_20_663
Author(s) : Tanaka K , Mizukawa K , Ogawa N , Mori A
Ref : Neurochemical Research , 20 :663 , 1995
Abstract :

We examined by morphological methodology the effect of (S)-N-ethyl-3-[(1-dimethyl-amino)ethyl]-N-methyl-phenylcarbamate hydrogentartrate (ENA-713), an acetylcholinesterase (AChE) inhibitor, on ischemia-induced neuronal death in the gerbil hippocampus due to a 5-min ligation of bilateral common carotid arteries after light ether anesthesia. Pyramidal cells had been decreased to 27% of sham-operated controls and the number of hypertrophic astrocytes expressing glial fibrillary acidic protein (GFAP) markedly increased in the hippocampal CA1 subfield 14 days after ischemia. However, post-ischemic administration of ENA-713 (three times 0.2 mg/kg, i.p.) significantly ameliorated this ischemia-induced decrease in the number of pyramidal cells by 47% of sham-operated controls, furthermore, it reduced the ischemia-induced accumulation of GFAP-positive astrocyte in the CA1 region. Together with previous results showing that ENA-713 protected against the ischemia-induced cholinergic abnormalities in the gerbil brain and improved cholinergic dysfunctions in the senescent rat brain, our present findings suggest that ENA-713 prove to be useful for treatment with senile dementia such as cerebrovascular dementia.

PubMedSearch : Tanaka_1995_Neurochem.Res_20_663
PubMedID: 756636

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Citations formats

Tanaka K, Mizukawa K, Ogawa N, Mori A (1995)
Post-ischemic administration of the acetylcholinesterase inhibitor ENA-713 prevents delayed neuronal death in the gerbil hippocampus
Neurochemical Research 20 :663

Tanaka K, Mizukawa K, Ogawa N, Mori A (1995)
Neurochemical Research 20 :663