Tandon_2006_Drug.Chem.Toxicol_29_333

This study was designed to investigate the effects of lithium in adult rat brain under different dietary protein regimens. Lithium as carbonate was given at a dose of 1.1 g/kg diet to female rats fed normal (18% protein), low protein (8% protein), and high protein (30% protein) diets for 30 days. Lithium treatment resulted in a significant decrease in the levels of norepinephrine, dopamine, and serotonin in the cerebrum of the rat brain. Further, administration of lithium to rats fed low protein (LP) and high protein (HP) diets also showed a significant decrease in the levels of norepinephrine and dopamine but caused no significant change in the serotonin concentration. Lithium administration to normal diet, LP, and HP groups resulted in a significant increase in the activities of acetylcholinesterase and monoamine oxidase. Lithium treatment led to decrease in the activity of enzyme Na+ K+ ATPase in all groups. On the second day, the LP group showed enhanced transfer latency (TL), a dependent variable to study elevated plus-maze test, whereas HP diet went from 34% reduction to normal. On the other hand, lithium administration restored the already enhanced TL in the LP group. The study concludes that lithium treatment to protein-deficient cases may not further aggravate the effects of protein-deficient conditions, but it may afford protection.