Taslimi_2017_J.Biochem.Mol.Toxicol_31(11)_

In this paper, synephrine and phenylephrine compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I and II, alpha-amylase, alpha-glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Synephrine and phenylephrine had Ki values of 199.02 +/- 16.01 and 65.01 +/- 5.00 muM against hCA I and 336.02 +/- 74.01 and 92.04 +/- 18.03 muM against hCA II, respectively. On the other hand, their Ki values were found to be 169.10 +/- 80.03 and 88.03 +/- 5.01 nM against AChE and 177.06 +/- 6.01 and 78.03 +/- 3.05 nM against BChE, respectively. alpha-Amylase and alpha-glycosidase enzymes were easily inhibited by these compounds. alpha-Glycosidase inhibitors, generally defined to as starch blockers, are anti-diabetic drugs that help to decrease post comestible blood glucose levels.