Taslimi_2017_J.Biochem.Mol.Toxicol_31_

Natural products from food and plant sources have been used for medicinal usage for ages. Also, natural products with therapeutic significance are compounds derived from animals, plants, or any microorganism. In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). These phenolic compounds were tested for the inhibition of alpha-glycosidase, hCA I, hCA II, AChE, and BChE enzymes and demonstrated efficient inhibition profiles with Ki values in the range of 3.70 +/- 0.92-79.66 +/- 20.81 nM against hCA I, 2.98 +/- 0.33-84.88 +/- 40.32 nM against hCA II, 4.93 +/- 2.01-593.60 +/- 134.74 nM against alpha-Gly, 0.52 +/- 0.18-46.80 +/- 17.15 nM against AChE, and 1.25 +/- 0.22-32.08 +/- 2.68 against BChE.