Title : The role of PON1 and CYP2D6 genes in susceptibility to organophosphorus chronic intoxication in Egyptian patients - Tawfik Khattab_2015_Neurotoxicol_53_102 |
Author(s) : Tawfik Khattab AM , Zayed AA , Ahmed AI , AbdelAal AG , Mekdad AA |
Ref : Neurotoxicology , 53 :102 , 2015 |
Abstract :
BACKGROUND: Paraoxonase-1 (PON1) activity toward organophosphorus(OP) compounds shows inter-individual variations, rendering the identification of individuals' PON1 allozymes valuable in treating patients suffering from organophosphorus intoxication. One of the most important cytochrome P450 monooxygenases (CYPs) is CYP2D6. The CYP2D6 G1934A polymorphism leads to good, poor or no enzyme activity. Genetic testing helps identification of high risk individuals as well as management of chronic intoxicated patients. OBJECTIVE: to investigate a possible association between genetic polymorphisms of PON1 Q192R, and CYP2D6 G1934A as well as PON1 and pseudo-cholinesterase (PChE) enzyme activity levels and chronic organophosphate exposed patients, and hence, susceptibility for organophosphorus chronic poisoning. DESIGN AND |
PubMedSearch : Tawfik Khattab_2015_Neurotoxicol_53_102 |
PubMedID: 26723569 |
Tawfik Khattab AM, Zayed AA, Ahmed AI, AbdelAal AG, Mekdad AA (2015)
The role of PON1 and CYP2D6 genes in susceptibility to organophosphorus chronic intoxication in Egyptian patients
Neurotoxicology
53 :102
Tawfik Khattab AM, Zayed AA, Ahmed AI, AbdelAal AG, Mekdad AA (2015)
Neurotoxicology
53 :102