Tayebati_2001_Brain.Res_889_256

Reference

Title : Muscarinic cholinergic receptors subtypes in rat cerebellar cortex: light microscope autoradiography of age-related changes - Tayebati_2001_Brain.Res_889_256
Author(s) : Tayebati SK , Vitali D , Scordella S , Amenta F
Ref : Brain Research , 889 :256 , 2001
Abstract :

Muscarinic cholinergic M1-M5 receptor subtypes were investigated in the cerebellar cortex of Fischer 344 rats aged 6 (young), 15 (adult) and 22 months (senescent) by combined kinetic and equilibrium binding and light microscope autoradiography. In young rats the rank order of receptor density was M5<M4<M3 and M3<M5<M4 in the molecular and granular layers, respectively. M1, M2, M4 and M5 receptors were also observed within Purkinje neurons. M1 receptor did not show age-related changes as well as the M2 receptor in the molecular layer. In this layer, M3-M5 receptors were increased in senescent compared to younger rats. In the granular layer the expression of M2 and M5 muscarinic receptors was similar in young and senescent rats and higher in adult rats. M3 and M4 receptors were more in adult and senescent rats compared to young animals. In Purkinje neurons, a slight-to-moderate age-related increase of M1 and M5 receptor expression was observed.

PubMedSearch : Tayebati_2001_Brain.Res_889_256
PubMedID: 11166715

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Citations formats

Tayebati SK, Vitali D, Scordella S, Amenta F (2001)
Muscarinic cholinergic receptors subtypes in rat cerebellar cortex: light microscope autoradiography of age-related changes
Brain Research 889 :256

Tayebati SK, Vitali D, Scordella S, Amenta F (2001)
Brain Research 889 :256