| Title : Development of the biocatalytic resolution of 2-azabicyclo[2.2.1]hept-5-en-3-one as an entry to single- enantiomer carbocyclic nucleosides - Taylor_1993_Tetrahedron.Asymmetry_4_1117 |
| Author(s) : Stephen J C Taylor SJC , Raymond McCague R , Richard Wisdom R , Carol Lee C , Karea Dickson K , Graham Ruecroft G , Fergal O'Brien F , Jennifer Littlechild J , Jennifer Bevan J , Stanley M Roberts SM , Evans CT |
| Ref : Tetrahedron Asymmetry , 4 :1117 , 1993 |
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Abstract :
For the resolution of the bicyclic lactam 2-azabicyclo[2.2.l]hept-5-en3-one, efficient whole cell biocatalysts have been identified and from these, enzymes (lactamases) have been isolated. While the two enzymes obtained act on different enantiomers of the lactam, either can be used in scaleable processes to obtain synthons for carbocyclic nucleosides having the natural configuration. |
| PubMedSearch : Taylor_1993_Tetrahedron.Asymmetry_4_1117 |
| PubMedID: |
| Substrate | 2-azabicyclo[2.2.1]hept-5-en-3-one |
Stephen J C Taylor SJC, Raymond McCague R, Richard Wisdom R, Carol Lee C, Karea Dickson K, Graham Ruecroft G, Fergal O'Brien F, Jennifer Littlechild J, Jennifer Bevan J, Stanley M Roberts SM, Evans CT (1993)
Development of the biocatalytic resolution of 2-azabicyclo[2.2.1]hept-5-en-3-one as an entry to single- enantiomer carbocyclic nucleosides
Tetrahedron Asymmetry
4 :1117
Stephen J C Taylor SJC, Raymond McCague R, Richard Wisdom R, Carol Lee C, Karea Dickson K, Graham Ruecroft G, Fergal O'Brien F, Jennifer Littlechild J, Jennifer Bevan J, Stanley M Roberts SM, Evans CT (1993)
Tetrahedron Asymmetry
4 :1117