Thoen_2021_Clin.Res.Hepatol.Gastroenterol_45_101638

Reference

Title : Low levels of Lysosomal Acid Lipase (LAL) activity increases necroinflammation in adult patients with biopsy-proven metabolic associated fatty liver disease - Thoen_2021_Clin.Res.Hepatol.Gastroenterol_45_101638
Author(s) : Thoen RU , Longo L , Neto SC , Alvares-da-Silva MR
Ref : Clin Res Hepatol Gastroenterol , 45 :101638 , 2021
Abstract :

INTRODUCTION AND OBJECTIVE: Metabolic associated fatty liver disease (MAFLD), characterized by intra-hepatic fat accumulation, will soon be the leading cause of end-stage liver disease. Lysosomal Acid Lipase (LAL) is a key enzyme in lipid metabolism. We investigated its activity in patients with biopsy-proven MAFLD. METHODS: Prospective cross-sectional study in patients with biopsy-proven MAFLD. Blood LAL-activity (pmol/punch/h) was measured with dried blood spot extracts using Lalistat 2. Demographic, clinical, and laboratory data were collected. RESULTS: 101 adult patients were recruited. Among them, 11.9% had a diagnosis of MAFLD without steatohepatitis and 88.1% had MAFLD with steatohepatitis. The median of LAL-activity in patients with MAFLD was 76.8 pmol/punch/h. MAFLD patients with steatohepatitis showed an increase in gamma-glutamyl transferase (p = 0.042), insulin (p = 0.001), homeostatic model assessment for insulin resistance (HOMA-IR, p = 0.001) and advanced liver fibrosis (p < 0.001), compared to cases of MAFLD without steatohepatitis. There was no statistical difference in LAL-activity between the cases (p = 0.296). When considering LAL-activity above and below 77 pmol/punch/h as a cut-off value, patients with reduced LAL-activity had a significant increase in necroinflammatory activity according to the METAVIR score (p = 0.040), and NAFLD activity score (NAS, p = 0.031) compared to cases with higher LAL-activity. CONCLUSION: Our findings suggest that reduced LAL-activity is associated with increased necroinflammatory activity and severity of the NAS. A better knowledge of the role of LAL may provide new insights into the pathogenesis and progression of MAFLD.

PubMedSearch : Thoen_2021_Clin.Res.Hepatol.Gastroenterol_45_101638
PubMedID: 33662773

Related information

Inhibitor Lalistat-2

Citations formats

Thoen RU, Longo L, Neto SC, Alvares-da-Silva MR (2021)
Low levels of Lysosomal Acid Lipase (LAL) activity increases necroinflammation in adult patients with biopsy-proven metabolic associated fatty liver disease
Clin Res Hepatol Gastroenterol 45 :101638

Thoen RU, Longo L, Neto SC, Alvares-da-Silva MR (2021)
Clin Res Hepatol Gastroenterol 45 :101638