Title : Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice - Thomsen_2007_Psychopharmacology.(Berl)_192_97 |
Author(s) : Thomsen M , Wortwein G , Fink-Jensen A , Woldbye DP , Wess J , Caine SB |
Ref : Psychopharmacology (Berl) , 192 :97 , 2007 |
Abstract :
RATIONALE: Schizophrenic patients show decreased measures of sensorimotor gating, such as prepulse inhibition of startle (PPI). In preclinical models, these measures may be used to predict antipsychotic activity. While current antipsychotic drugs act largely at dopamine receptors, the muscarinic acetylcholine receptors offer promising novel pharmacotherapy targets. Of these, the M(5) receptor gene was recently implicated in susceptibility to schizophrenia. Due to the lack of selective ligands, muscarinic receptor knockout mice have been generated to elucidate the roles of the five receptor subtypes (M(1)-M(5)). OBJECTIVES: Here, we used M(5) receptor knockout (M(5)-/-) mice to investigate the involvement of M(5) receptors in behavioral measures pertinent to schizophrenia. We tested the hypothesis that disruption of M(5) receptors affected PPI or the effects of muscarinic or dopaminergic agents in PPI or psychomotor stimulation. MATERIALS AND |
PubMedSearch : Thomsen_2007_Psychopharmacology.(Berl)_192_97 |
PubMedID: 17310388 |
Thomsen M, Wortwein G, Fink-Jensen A, Woldbye DP, Wess J, Caine SB (2007)
Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice
Psychopharmacology (Berl)
192 :97
Thomsen M, Wortwein G, Fink-Jensen A, Woldbye DP, Wess J, Caine SB (2007)
Psychopharmacology (Berl)
192 :97