| Title : Influence of trauma on plasma elimination of exogenous fat and on lipoprotein lipase activity and mass - Thorne_2005_Clin.Nutr_24_66 |
| Author(s) : Thorne A , Aberg W , Carneheim C , Olivecrona T , Nordenstrom J |
| Ref : Clin Nutr , 24 :66 , 2005 |
| Abstract : BACKGROUND: Trauma is followed by an increased plasma clearance and oxidation of exogenous fat but the underlying mechanism is not fully understood. AIM: To examine the influence of a surgical trauma on the plasma elimination of exogenous triglycerides (TG) and its relationship with lipoprotein lipase (LPL) activity and LPL mass. METHODS: Nine patients underwent a hypertriglyceridaemic clamp and a lipolytic capacity test before and after open abdominal surgery. The infusion rate was adjusted to maintain a stable TG concentration of 4 mmol x l(-1) during 180 min. The lipolytic capacity was determined as the change in LPL activity and mass following a bolus dose of 100 IU x kg BW(-1) heparin sodium. RESULTS: Postoperatively, the plasma elimination rate of fat was 2.6 times higher (P<0.001). Infusion of lipids in the postoperative state was followed by a smaller rise in free fatty acids (P<0.05) in comparison with the preoperative situation. The postoperative basal fasting LPL activity was half of that in the preoperative state and the LPL activity rose almost two-fold during the clamp. The heparin-induced rises in LPL activity and LPL mass were similar (n.s.) before and after surgery. CONCLUSIONS: A moderate surgical trauma is accompanied by a greater than two-fold rise in plasma elimination rate of exogenous fat despite a lower basal LPL activity and a virtually unchanged LPL pattern during infusion of lipids. Our study demonstrates that although trauma may substantially enhance the fat elimination capacity a significant proportion of the infused fat is not utilized for metabolic purposes. |
| ESTHER : Thorne_2005_Clin.Nutr_24_66 |
| PubMedSearch : Thorne_2005_Clin.Nutr_24_66 |
| PubMedID: 15681103 |
Thorne A, Aberg W, Carneheim C, Olivecrona T, Nordenstrom J (2005)
Influence of trauma on plasma elimination of exogenous fat and on lipoprotein lipase activity and mass
Clin Nutr
24 :66
Thorne A, Aberg W, Carneheim C, Olivecrona T, Nordenstrom J (2005)
Clin Nutr
24 :66