Tian_1996_Neurosci.Lett_209_134

Reference

Title : Developmental age-dependent upregulation of choline acetyltransferase and vesicular acetylcholine transporter mRNA expression in neonatal rat septum by nerve growth factor - Tian_1996_Neurosci.Lett_209_134
Author(s) : Tian X , Sun X , Suszkiw JB
Ref : Neuroscience Letters , 209 :134 , 1996
Abstract :

We examined the effect of intraventricular injection of nerve growth factor (NGF) on the choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) mRNA expression in the septa of neonatal rats. Rat pups were injected with 2.5 S NGF or cytochrome-c (control) on postnatal days (PN) 4 and 18, and sacrificed 3 days after injections for analysis of ChAT and VAChT mRNA levels by dot-blot hybridization of total septal RNA. In the NGF-treated pups, the ChAT and VAChT mRNA levels were elevated 3- and 2-fold, respectively, at PN7, and 1.8- and 1.3-fold at PN21. These results indicate that (1) NGF upregulates the expression of both ChAT and VAChT genes, (2) NGF has a greater effect on the expression of ChAT mRNA than VAChT mRNA, and (3) the effect of exogenous NGF on the expression of both genes diminishes with developmental age.

PubMedSearch : Tian_1996_Neurosci.Lett_209_134
PubMedID: 8762000

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Citations formats

Tian X, Sun X, Suszkiw JB (1996)
Developmental age-dependent upregulation of choline acetyltransferase and vesicular acetylcholine transporter mRNA expression in neonatal rat septum by nerve growth factor
Neuroscience Letters 209 :134

Tian X, Sun X, Suszkiw JB (1996)
Neuroscience Letters 209 :134