| Title : Paraoxonase gene mutations in amyotrophic lateral sclerosis - Ticozzi_2010_Ann.Neurol_68_102 |
| Author(s) : Ticozzi N , LeClerc AL , Keagle PJ , Glass JD , Wills AM , van Blitterswijk M , Bosco DA , Rodriguez-Leyva I , Gellera C , Ratti A , Taroni F , McKenna-Yasek D , Sapp PC , Silani V , Furlong CE , Brown RH, Jr. , Landers JE |
| Ref : Annals of Neurology , 68 :102 , 2010 |
|
Abstract :
Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the PON genes and sporadic amyotrophic lateral sclerosis (ALS). We now report that in genomic DNA from individuals with familial and sporadic ALS, we have identified at least 7 PON gene mutations that are predicted to alter PON function. |
| PubMedSearch : Ticozzi_2010_Ann.Neurol_68_102 |
| PubMedID: 20582942 |
Ticozzi N, LeClerc AL, Keagle PJ, Glass JD, Wills AM, van Blitterswijk M, Bosco DA, Rodriguez-Leyva I, Gellera C, Ratti A, Taroni F, McKenna-Yasek D, Sapp PC, Silani V, Furlong CE, Brown RH, Jr., Landers JE (2010)
Paraoxonase gene mutations in amyotrophic lateral sclerosis
Annals of Neurology
68 :102
Ticozzi N, LeClerc AL, Keagle PJ, Glass JD, Wills AM, van Blitterswijk M, Bosco DA, Rodriguez-Leyva I, Gellera C, Ratti A, Taroni F, McKenna-Yasek D, Sapp PC, Silani V, Furlong CE, Brown RH, Jr., Landers JE (2010)
Annals of Neurology
68 :102