Tomke_2015_Ultrason.Sonochem_27_241

Cinnamyl acetate is known for its use as flavor and fragrance material in different industries such as food, pharmaceutical, cosmetic etc. This work focuses on ultrasound assisted lipase (Novozym 435) catalyzed synthesis of cinnamyl acetate via transesterification of cinnamyl alcohol and vinyl acetate in non-aqueous, solvent free system. Optimization of various parameters shows that a higher yield of 99.99% can be obtained at cinnamyl alcohol to vinyl acetate ratio of 1:2 with 0.2% of catalyst, at 40 degrees C and 150rpm, with lower ultrasound power input of 50W (Ultrasound intensity 0.81W/cm(2)), at 25kHz frequency, 50% duty cycle. Further, the time required for the maximum conversion is reduced to 20min as compared to 60min of conventional process. Similarly, the enzyme can be successfully reused seven times without loss of enzyme activity. Thus, ultrasound helps to enhance the enzyme catalyzed synthesis of flavors.