| Title : [Effect of reversible inhibitors on the reaction capacity of functional portions of the active center of acetylcholinesterase] - Tonkopii_1978_Biull.Eksp.Biol.Med_86_441 |
| Author(s) : Tonkopii VD , Ardab'eva TV |
| Ref : Biulleten Eksperimentalnoi Biologii i Meditsiny , 86 :441 , 1978 |
|
Abstract :
The effect of galanthamine, tacrine, and oxazyl (ambenomum) on human red cells acetylcholinesterase phosphorylation by armine and Gd-42 (o-ethyl-s-beta-ethylthioethyl ester of methylthiophosphinic acid) was studied. In the presence of galanthamine phosphororganic inhibitors interacted only with the active center of the enzyme, the anionic site of which was not occupied by the reversible inhibitor. Tacrine and oxazyl decreased the reactivity of the free enzyme and the rate of its phosphorylation. |
| PubMedSearch : Tonkopii_1978_Biull.Eksp.Biol.Med_86_441 |
| PubMedID: 708873 |
Tonkopii VD, Ardab'eva TV (1978)
[Effect of reversible inhibitors on the reaction capacity of functional portions of the active center of acetylcholinesterase]
Biulleten Eksperimentalnoi Biologii i Meditsiny
86 :441
Tonkopii VD, Ardab'eva TV (1978)
Biulleten Eksperimentalnoi Biologii i Meditsiny
86 :441