| Title : Reversible inhibition of human acetylcholinesterase by methoxypyridinium species - Topczewski_2013_Bioorg.Med.Chem.Lett_23_5786 |
| Author(s) : Topczewski JJ , Lodge AM , Yasapala SN , Payne MK , Keshavarzi PM , Quinn DM |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :5786 , 2013 |
|
Abstract :
The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. Currently no antidote is known that resurrects the phosphyl-AChE complex once aging has occurred. This report characterizes the affinities of over 30 new AChE inhibitors which could act as resurrecting agents for the aged AChE-OP adduct. |
| PubMedSearch : Topczewski_2013_Bioorg.Med.Chem.Lett_23_5786 |
| PubMedID: 24076173 |
Topczewski JJ, Lodge AM, Yasapala SN, Payne MK, Keshavarzi PM, Quinn DM (2013)
Reversible inhibition of human acetylcholinesterase by methoxypyridinium species
Bioorganic & Medicinal Chemistry Lett
23 :5786
Topczewski JJ, Lodge AM, Yasapala SN, Payne MK, Keshavarzi PM, Quinn DM (2013)
Bioorganic & Medicinal Chemistry Lett
23 :5786