Torre_2012_Molecules_17_12072

(E)-2-(benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles are described as a new class of selective inhibitors of acetylcholinesterase AChE The most potent compound in the series exhibited good AChE inhibitory activity IC(50 64 micro;M Compound 7f was found to be more selective than galanthamine in inhibiting AChE and it showed a moderate selectivity index Kinetic studies on AChE indicated that a competitive type of inhibition pattern exist for these acrylonitrile derivates Molecular docking models of the ligand-AChE complexes suggest that compound 7g is located on the periphery of the AChE active site.