| Title : Highly sensitive acetylcholine biosensing via chemical amplification of enzymatic processes in nanochannels - Toum_2022_Chem.Commun.(Camb)__ |
| Author(s) : Toum Terrones Y , Laucirica G , Cayon VM , Fenoy GE , Cortez ML , Toimil-Molares ME , Trautmann C , Mamisolle WA , Azzaroni O |
| Ref : Chem Commun (Camb) , : , 2022 |
|
Abstract :
Acetylcholinesterase-modified nanochannels are proposed as reliable and reproducible nanofluidic sensors for highly sensitive detection of acetylcholine. The operation mechanism relies on the use of weak polyelectrolytes as "chemical amplifiers" that adjust/reconfigure the nanochannel surface charge in the presence of local pH changes induced by the enzymatic reaction. Experimental results show that the presence of acetylcholine can be transduced into measurable ionic signals with a low limit of detection. |
| PubMedSearch : Toum_2022_Chem.Commun.(Camb)__ |
| PubMedID: 35997520 |
Toum Terrones Y, Laucirica G, Cayon VM, Fenoy GE, Cortez ML, Toimil-Molares ME, Trautmann C, Mamisolle WA, Azzaroni O (2022)
Highly sensitive acetylcholine biosensing via chemical amplification of enzymatic processes in nanochannels
Chem Commun (Camb)
:
Toum Terrones Y, Laucirica G, Cayon VM, Fenoy GE, Cortez ML, Toimil-Molares ME, Trautmann C, Mamisolle WA, Azzaroni O (2022)
Chem Commun (Camb)
: