Trinh_2012_J.Nat.Prod_75_2012

Bioassay-guided fractionation of an extract of leaves of Macaranga kurzii yielded four new compounds, a stilbene (furanokurzin, 1) and three flavonoids (macakurzin A-C, 2-4). Nine known compounds were also isolated (5-13). Their structures were determined by spectroscopic analyses including MS and 2D NMR. The isolates were all evaluated for acetylcholinesterase inhibitory activity. Compound 6 (trans-3,5-dimethoxystilbene) exhibited the greatest activity (IC50 9 muM). Cytotoxic evaluation against KB cells showed that compound 7 had an IC50 of 4 muM, followed by 11 (IC50 10 muM) and 3 (IC50 13 muM).