Troudi_2012_Toxicol.Ind.Health_28_820

Gibberellic acid GA(3 is a plant growth regulator used in agriculture worldwide The present study investigated the propensity of GA(3 to induce hematological disorders Pregnant Wistar rats were randomly divided into two groups group I served as controls group II received orally GA(3 200 ppm from the 14th day of pregnancy until day 14 after delivery GA(3 reduced the number of red blood cells hemoglobin concentration and hematocrit in suckling rats while these parameters remained unchanged in their mothers White blood cells increased in mothers and were unchanged in their pups Several studies have associated these hematological disorders with oxidative stress In fact GA(3 treatment revealed in erythrocytes a significant increase in malondialdehyde levels and a decrease in antioxidant enzyme activities such as superoxide dismutase catalase and glutathione peroxidase Moreover a significant decline was observed in acetylcholinesterase activity glutathione nonprotein thiols and vitamin C levels.