Title : The role of acetone in the [omim][BF4]-mediated adverse effects on tissues of mussels, human lymphocytes and the fruit fly Drosophila melanogaster - Tsarpali_2017_J.Hazard.Mater_333_339 |
Author(s) : Tsarpali V , Goutas A , Karyda A , Efthimiou I , Antonopoulou M , Drosopoulou E , Vlastos D , Konstantinou I , Mavragani-Tsipidou P , Dailianis S |
Ref : J Hazard Mater , 333 :339 , 2017 |
Abstract :
The present study investigated [omim][BF4]-mediated adverse effects on biological models widely used in toxicological studies. Specifically, mussels of the genus Mytilus, human lymphocytes and fruit flies of the species Drosophila melanogaster, were exposed to [omim][BF4] at concentrations ranging from micro- to milligrams per liter, with or without the presence of acetone as a carrier solvent and thereafter [omim][BF4]-mediated adverse effects were analyzed appropriately (stress indices, such as lipid peroxidation byproducts, acetylcholinesterase/AChE activity and micronucleus/MN formation frequency, in mussel gills, Cytokinesis Block Micronucleus/CBMN assay and SMART test in human lymphocytes and fruit flies respectively). LC-MS-TOF analysis was also performed for elucidating [omim][BF4] mode of action in the presence of the carrier solvent. The results showed the toxic potential of [omim][BF4], as well as acetone's ability to attenuate [omim][BF4]-mediated toxicity in almost all cases, probably due to the significant effect of acetone on the hydrophilic-lipophilic character and the viscosity of [omim][BF4], as well as its interaction and permeability on the cell membranes. The slight involvement of acetone in the attenuation of [omim][BF4]-mediated genotoxic effects on D. melanogaster could be due to species feeding experimental conditions, thus favoring the induction of antioxidant defense system against the [omim][BF4]-mediated effects in all cases. |
PubMedSearch : Tsarpali_2017_J.Hazard.Mater_333_339 |
PubMedID: 28380406 |
Tsarpali V, Goutas A, Karyda A, Efthimiou I, Antonopoulou M, Drosopoulou E, Vlastos D, Konstantinou I, Mavragani-Tsipidou P, Dailianis S (2017)
The role of acetone in the [omim][BF4]-mediated adverse effects on tissues of mussels, human lymphocytes and the fruit fly Drosophila melanogaster
J Hazard Mater
333 :339
Tsarpali V, Goutas A, Karyda A, Efthimiou I, Antonopoulou M, Drosopoulou E, Vlastos D, Konstantinou I, Mavragani-Tsipidou P, Dailianis S (2017)
J Hazard Mater
333 :339