| Title : Effects of toluene on regulation of adenylyl cyclase by stimulation of G-protein-coupled receptors expressed in CHO cells - Tsuga_1999_Jpn.J.Pharmacol_81_305 |
| Author(s) : Tsuga H , Wang RS , Honma T |
| Ref : Japanese Journal of Pharmacology , 81 :305 , 1999 |
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Abstract :
We determined the effects of toluene exposure on activation or inhibition of adenylyl cyclase by stimulating human beta2-adrenergic receptors (beta2-AR) and muscarinic acetylcholine receptor (mAChR) m2 subtypes, respectively, expressed in CHO cells. The formation of cAMP via beta2-AR stimulation was slightly but not significantly facilitated in the presence of 3.7 microM toluene. On the other hand, the inhibition of adenylyl cyclase by 10 microM of carbamylcholine stimulation of mAChR m2 subtypes was attenuated in the presence of toluene. These results strongly suggest that toluene affects activation of Gi rather than Gs. |
| PubMedSearch : Tsuga_1999_Jpn.J.Pharmacol_81_305 |
| PubMedID: 10622220 |
Tsuga H, Wang RS, Honma T (1999)
Effects of toluene on regulation of adenylyl cyclase by stimulation of G-protein-coupled receptors expressed in CHO cells
Japanese Journal of Pharmacology
81 :305
Tsuga H, Wang RS, Honma T (1999)
Japanese Journal of Pharmacology
81 :305