Title : Regulation of cerebral blood flow response to somatosensory stimulation through the cholinergic system: a positron emission tomography study in unanesthetized monkeys - Tsukada_1997_Brain.Res_749_10 |
Author(s) : Tsukada H , Kakiuchi T , Ando I , Shizuno H , Nakanishi S , Ouchi Y |
Ref : Brain Research , 749 :10 , 1997 |
Abstract :
The effects of scopolamine, a muscarinic cholinergic receptor antagonist and physostigmine, a cholinesterase inhibitor, on the regional cerebral blood flow (rCBF) response to vibrotactile stimulation of the forepaw were studied in the brain of unanesthetized monkeys using 15O-labeled water and high resolution positron emission tomography. Before scopolamine administration, vibrotactile stimulation produced a significant increase in the rCBF response in the contralateral somatosensory cortex of the monkey brain. Intravenous administration of scopolamine at doses ranging from 1 to 500 microg/kg resulted in a dose-dependent reduction of the rCBF response. The rCBF response abolished by scopolamine (50 microg/kg) was recovered by administration of physostigmine (10 microg/kg). On the other hand, the regional cerebral metabolic rate of glucose (rCMRglc) response, measured with [18F]-2-fluoro-2-deoxy-D-glucose, to the same stimulation was unchanged by administration of either scopolamine and/or physostigmine. These results suggested that cholinergic mechanisms might be involved in regulation of the coupling between neuronal activity and rCBF response, not between the activity and rCMRglc response. |
PubMedSearch : Tsukada_1997_Brain.Res_749_10 |
PubMedID: 9070622 |
Tsukada H, Kakiuchi T, Ando I, Shizuno H, Nakanishi S, Ouchi Y (1997)
Regulation of cerebral blood flow response to somatosensory stimulation through the cholinergic system: a positron emission tomography study in unanesthetized monkeys
Brain Research
749 :10
Tsukada H, Kakiuchi T, Ando I, Shizuno H, Nakanishi S, Ouchi Y (1997)
Brain Research
749 :10