| Title : Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors - Turkan_2019_Bioorg.Chem_86_420 |
| Author(s) : Turkan F , Cetin A , Taslimi P , Karaman M , Gulcin I |
| Ref : Bioorg Chem , 86 :420 , 2019 |
|
Abstract :
A series of substituted pyrazole compounds (1-8 and 9a, b) were synthesized and their structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole derivatives (1-8 and 9a, b) were emerged as effective inhibitors of the cytosolic carbonic anhydrase I and II isoforms (hCA I and II) and acetylcholinesterase (AChE) enzymes with Ki values in the range of 1.03+/-0.23-22.65+/-5.36microM for hCA I, 1.82+/-0.30-27.94+/-4.74microM for hCA II, and 48.94+/-9.63-116.05+/-14.95microM for AChE, respectively. Docking studies were performed for the most active compounds, 2 and 5, and binding mode between the compounds and the receptors were determined. |
| PubMedSearch : Turkan_2019_Bioorg.Chem_86_420 |
| PubMedID: 30769267 |
Turkan F, Cetin A, Taslimi P, Karaman M, Gulcin I (2019)
Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors
Bioorg Chem
86 :420
Turkan F, Cetin A, Taslimi P, Karaman M, Gulcin I (2019)
Bioorg Chem
86 :420