Turkan_2021_J.Biomol.Struct.Dyn_39_3693

Inhibitory effect of the complexes on some metabolic enzyme results demonstrated that the enzymes inhibited by ligand and it's complex molecules at the micromolar level. The best inhibition effect for alpha-Gly enzyme against cobalt complex with 3.77 +/- 0.58 microM, Ki values were observed. For AChE, and BChE enzymes against SM-Co complex with 74.23 +/- 5.02 microM and 101.21 +/- 12.84 microM Ki values were observed respectively. Molecular docking studies were performed to compare the biological activities of ligands and ligand complexes against enzymes whose names are Achethylcholinesterase (AChE) for ID 4M0E, Butyrylcholinesterase (BChE) for ID 5NN0, alpha glycosidase (alpha-Gly) for ID 1XSI respectively. Anticancer properties of the complexes studied. The doses of all compounds caused significant reductions in MCF-7 cell viability. Zr compound showed the best cytotoxic activity against the MCF-7 cell. SM ligand administered to PC-3 cells exhibited a more pronounced cytotoxic effect than the SM-Co and Zr compounds.