| Title : Paraoxonase-1 activity determination via paraoxon substrate yields no significant difference in mild hyperhomocysteinemia - Turkeli_2010_Int.J.Cardiol_145_42 |
| Author(s) : Turkeli H , Cayci T , Akgul E , Macit E , Yaman H , Aydin I , Demirin H , Alacam H , Ozkan E , Cakir E , Deren O , Erbil MK , Kunak ZI , Burat K , Akman S |
| Ref : Int J Cardiol , 145 :42 , 2010 |
|
Abstract :
Elevated plasma homocystein (Hcy) level has been recognized as an important risk factor for a number of cardiovascular diseases, peripheral arterial occlusive disease and venous thrombosis. A part of Hcy in the organism is turned to homocysteine thiolactone (HcyT) via a ring closure reaction, which gains rate in hyperhomocysteinemia, and in turn undergoes a hydrolytic reaction back to Hcy by paraoxonase enzyme (PON). Since this is a protective reflex action enzyme against hyperhomocysteinemia, we investigated how a mild hyperhomocysteinemic nutritional habit affected serum PON activity in a population-based study. The difference detected via enzymatic activity using the paraoxon substrate was statistically non-significant (p=0.19), suggesting a defective performance to reflect the expected significance. Determination of serum PON activity via substrate paraoxon yielded no significant difference in an acute mild hyperhomocysteinemic diet model in humans. |
| PubMedSearch : Turkeli_2010_Int.J.Cardiol_145_42 |
| PubMedID: 19419786 |
Turkeli H, Cayci T, Akgul E, Macit E, Yaman H, Aydin I, Demirin H, Alacam H, Ozkan E, Cakir E, Deren O, Erbil MK, Kunak ZI, Burat K, Akman S (2010)
Paraoxonase-1 activity determination via paraoxon substrate yields no significant difference in mild hyperhomocysteinemia
Int J Cardiol
145 :42
Turkeli H, Cayci T, Akgul E, Macit E, Yaman H, Aydin I, Demirin H, Alacam H, Ozkan E, Cakir E, Deren O, Erbil MK, Kunak ZI, Burat K, Akman S (2010)
Int J Cardiol
145 :42