Twayana_2022_JNMA.J.Nepal.Med.Assoc_60_881

INTRODUCTION: Major cases of poisoning are associated with organophosphates. Cholinergic effects and an intermediate phase seen with organophosphate poisoning may implicate myopathy. Creatine kinase is a marker of muscle tissue damage. This study aimed to find out the mean serum creatine kinase among organophosphate poisoning cases in a tertiary care centre. METHODS: A descriptive cross-sectional study was carried out among organophosphate poisoning cases in a tertiary care hospital from 13 October 2017 to 30 March 2018. Ethical approval was taken from the Institutional Review Committee [Reference number: 117(6-11-E) 2/074/075]. Blood samples were assayed for serum acetylcholinesterase in the pharmacology laboratory and for serum creatine kinase and lactate dehydrogenase in the biochemistry laboratory. Low serum acetylcholinesterase was taken as the basis for the establishment of organophosphate poisoning. A convenience sampling technique was used. Point estimate and 95% Confidence Interval were calculated. RESULTS: Among 103 organophosphate poisoning cases, the mean serum creatine kinase was 931.35+/-446.60 IU/l (845.10-1017.60, 95% Confidence Interval). CONCLUSIONS: The mean serum creatine kinase level among organophosphate poisoning cases was higher than in other studies done in similar settings. KEYWORDS: acetylcholinesterase; creatine kinase; organophosphate poisoning; rhabdomyolysis.