| Title : Central nervous system-mediated hyperglycemic effects of NIK-247, a cholinesterase inhibitor, and MKC-231, a choline uptake enhancer, in rats - Uemura_1999_Jpn.J.Pharmacol_79_113 |
| Author(s) : Uemura K , Yoshioka S , Surina-Baumgartner DM , Tamagawa T , Miura H , Ueda M , Tamaya N , Iguchi A , Hotta N |
| Ref : Japanese Journal of Pharmacology , 79 :113 , 1999 |
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Abstract :
We investigated the effects of intracerebroventricular administration of NIK-247 (9-amino-2,3,5,6,7,8-hexahydro-1H-cyclo-penta(b)-quinoline monohydrate hydrochloride; a cholinesterase inhibitor) or MKC-231 (2-(2-oxypyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofur o[2,3-b]quinolin-4-yl) acetoamide; a choline uptake enhancer) on plasma glucose level in comparison with that of neostigmine administration in rats. The extents of NIK-247- and MKC-231-induced hyperglycemia were considerably less than that by neostigmine, suggesting that the potencies of the drugs to produce the peripheral hyperglycemia may be pharmacologically negligible. |
| PubMedSearch : Uemura_1999_Jpn.J.Pharmacol_79_113 |
| PubMedID: 10082325 |
| Inhibitor | NIK-247 |
Uemura K, Yoshioka S, Surina-Baumgartner DM, Tamagawa T, Miura H, Ueda M, Tamaya N, Iguchi A, Hotta N (1999)
Central nervous system-mediated hyperglycemic effects of NIK-247, a cholinesterase inhibitor, and MKC-231, a choline uptake enhancer, in rats
Japanese Journal of Pharmacology
79 :113
Uemura K, Yoshioka S, Surina-Baumgartner DM, Tamagawa T, Miura H, Ueda M, Tamaya N, Iguchi A, Hotta N (1999)
Japanese Journal of Pharmacology
79 :113