Umezawa_2005_Biopolymers_79_248

Reference

Title : CH\/pi hydrogen bonds as evidenced in the substrate specificity of acetylcholine esterase - Umezawa_2005_Biopolymers_79_248
Author(s) : Umezawa Y , Nishio M
Ref : Biopolymers , 79 :248 , 2005
Abstract :

The crystal structure of acetylcholine esterase (AchE) in complex with various inhibitors, investigated as drugs for improvement of the cognitive ability of early stage Alzheimer's disease, has been analyzed with the use of our program CHPI. A number of CH/pi hydrogen bonds have been disclosed in the binding of the inhibitors with Torpedo californica AchE. It has been demonstrated that, in order to be effective in the binding with AchE, C-H bonds in the inhibitor need not be polarized.

PubMedSearch : Umezawa_2005_Biopolymers_79_248
PubMedID: 16113998

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Citations formats

Umezawa Y, Nishio M (2005)
CH\/pi hydrogen bonds as evidenced in the substrate specificity of acetylcholine esterase
Biopolymers 79 :248

Umezawa Y, Nishio M (2005)
Biopolymers 79 :248